February 27, 2020


Deadly coronavirus comes in three variants, researchers find
Geneticists from Britain and Germany have mapped the evolutionary path of the coronavirus that causes Covid-19 and determined there are currently three versions of it
spreading around the world
The discovery of how the variants were formed and then spread could help scientists to identify its source and explain why it is so contagious.
The researchers analysed the first 160 complete viral genomes sequenced from human patients between December 24 and March 4, then reconstructed the early evolutionary pathway of Covid-19 in humans through its mutations.
“There are too many rapid mutations to neatly trace a Covid-19 family tree. We used a mathematical network algorithm to visualise all the plausible trees simultaneously,” said Peter Forster, a geneticist at University of Cambridge and lead author of the study.
“These techniques are mostly known for mapping the movements of prehistoric human populations through DNA. We think this is one of the first times they have been used to trace the infection routes of a coronavirus like Covid-19,” he said in a report about the study on the university’s website.
Type A was closest to the coronavirus discovered in bats and although found in Wuhan– the central China city that was the epicentre of the initial outbreak – was not the primary type there, they said.
Type A was also found in Americans who had lived in Wuhan, and in other patients diagnosed in the United States and Australia.
The most common variant found in Wuhan was type B, the study said, though this appeared not to have travelled much beyond East Asia before mutating, which the researchers said was probably due to some form of resistance to it outside that region.
Finally, type C was the variant found most often in Europe based on cases in France, Italy, Sweden and England. It had not been detected in any patients in mainland China, though had been found in samples from Singapore, Hong Kong and South Korea, the study said.
The researchers concluded that variant A was the root of the outbreak as it was most closely related to the virus found in bats and pangolins. Type B was derived from A, separated by two mutations, while type C was the “daughter” of variant B.
“The Wuhan B-type virus could be immunologically or environmentally adapted to a large section of the East Asian population,” Forster said.
“It may need to mutate to overcome resistance outside East Asia. We seem to see a slower mutation rate in East Asia than elsewhere, in this initial phase.”
The research also documented how people’s movements had helped the spread of the virus.
For example, the study suggested that one of the earliest introductions of the virus to Italy – found in a Mexican traveller who was diagnosed on February 28 – came via the first documented German infection – a person who worked for a company in Munich – on January 27.
The German contracted the infection from a Chinese colleague in Shanghai, who had recently been visited by her parents from Wuhan.
The researchers documented 10 mutations in the viral journey from Wuhan to Mexico.
“Because we have reconstructed the "family tree" (the evolutionary history) of the human virus, we can use this tree to trace infection routes from one human to the next, and thus have a statistical tool to suppress future infection when the virus tries to return,” Forster said.
He added that researchers can better determine when the outbreak started with the data.
“I hope this improved knowledge of the origin and spread will enable more precise computer simulations to predict which measures will be most effective,” he said.
Lu Jiahai, an epidemiologist at Sun Yat-sen University Guangzhou, the capital of Guangdong, said the study had provided a preliminary analysis of genomics and molecular variation.
“The virus mutates during spreading and has become more adapted to transmission among humans in different populations from different countries,” he said.
But as the variants were related to each other, tracking mutations within different groups could help to determine the origin of the virus, he said.
“This research indicates that the spread of the virus is increasingly adapted to different populations and therefore the pandemic needs to be taken seriously,” Lu said.
“People need to pay more attention to prevention and control … the virus may coexist with humans for a long time.”
THere's More

Post you might also like

All Posts
THere's More

Post you might also like

All Posts
What could stand in the way of increasing US exports? Rates
April 1, 2021

What could stand in the way of increasing US exports? Rates

United States Trade Representative (USTR) Katherine Tai, in releasing the 2021 National Trade Estimate (NTE) Report, provided a detailed inventory of significant foreign barriers to U.S. exports of goods and services, investment and electronic commerce.
Cariuma Claims to Launch ‘World’s Lowest Carbon Footprint Sneaker’
March 30, 2021

Cariuma Claims to Launch ‘World’s Lowest Carbon Footprint Sneaker’

Cariuma’s latest sneaker drills down on each of these areas, co-founder Fernando Porto said. The Ibi Slip-On features a bamboo-knit upper and sugarcane EVA outsole. Each is crafted from a single piece, saving on waste and reducing the number of steps required during manufacturing
H&M Foundation’s Planet-Positive ‘Manifesto’
March 29, 2021

H&M Foundation’s Planet-Positive ‘Manifesto’

Eager to shed its reputation as a purveyor of fast fashion, H&M has debuted an accelerated plan for achieving sustainable development goals set forth by the United Nations by 2030.
Dislodging the Suez Canal Ship Said to Need at Least a Week
March 28, 2021

Dislodging the Suez Canal Ship Said to Need at Least a Week

Dislodging the container vessel blocking the Suez Canal will take until at least Wednesday, a longer effort than initially feared that will amplify the disruption to global supply chains for everything from oil to grains to cars
January 30, 2021


Gemstones are mostly found in regions of our earth that are difficult to access. People who search for such treasures often expose themselves to the greatest dangers and hardships in the hope of perhaps making a profitable find after all.